A member of the Five, Nigel became an abnormal with the power of invisibility and was the basis for Wells' novel "The Invisible Man".
Unlike his fellow Five members, he is hinted at having been from a lower class background, and had a distaste for most of high society. He seemed to have been the only member of the Five who got on exceptionally well with Nikola Tesla, with the two constantly playfully trading barbs about their past. He was also the first person to notice the bizzare behavior of their fellow student Adam Worth. Having seen some of the man's experiments, he told Helen Magnus that rather than thinking of them as daring, he saw them as twisted.
Like most members of the Five, Griffin served as an agent for the Allies during World War II. He helped Magnus and Watson in preventing the Nazis from using a fire elemental against the Allied invasion fleet on D-Day.
Years later, in the 1960s, he died of natural causes. This would cause a problem; as the only way to secure the sole vial containing pure vampire blood needed to cure the Cabal's Lazarus virus would be for the entire Five group to pass a series of tests. Fortunately, Griffin had fathered a daughter, Anna Griffin, who herself had yet another daughter, Clara Griffin. Both inherited their father/grandfather's ability to cloak more or less at will.
Nigel Griffin was an unseen character for the first two and a half seasons, as he was both invisible and dead at the time of the series' main events.
In 2010, the creators of Sanctuary revealed that he would appear in the eighth episode of Season Three, which explores the past exploits of the Five.
It is notable that Griffin seemed not to have aged between the end of the 19th Century and the year 1944, but died of old age in the 60s.