Dr. Helen Magnus struggles to find closure after the destruction of many Sanctuaries around the world, while the team prepares to process and host hundreds of dispossessed Abnormals seeking refuge at Magnus’ home Sanctuary.
Dr. Helen Magnus investigates an unlikely “superhero” who is intent on thwarting crime in the city. But his good deeds are interfering with the work of the Sanctuary and unintentionally threatening the lives of innocent people everywhere.
One of the Sanctuary's research scientists is viciously attacked by a seemingly docile Abnormal. While Magnus tries to save the life of the scientist, Henry investigates the origin of the creature's uncharacteristic behavior.
Will and Magnus investigate a number of teenagers who mysteriously disappeared. Their investigation leads them to a hospital run by Tesla, who intends to bring back Vampire-kind. However, one of the "patients" finds a way to speed up the conversion process, which creates a more powerful type of vampire.
After receiving vital information from the head of the Tokyo Sanctuary(TATUYA ISHII), the team starts a worldwide investigation that could have alarming global consequences. Magnus, Will and Kate travel to Mumbai, India to investigate a murder and connection to the Cult of Kali, an ancient cult whose followers can foretell disaster. But when Will falls ill and then disappears, Magnus knows they are dealing with something extremely powerful… and Will is somehow linked to the mystery. First half of the two-part season finale.